delichon 10 hours ago

Chromosomal sex is established at conception but physical differentiation occurs later. The idea that all humans start as female is mistaken. It stems from the observation that in the absence of male specific signals embryos will follow a developmental pathway that results in female characteristics. But biologically speaking embryos are not inherently female. They start in an undifferentiated "bipotential" state.

  • n4r9 6 hours ago

    I'm curious why the executive order avoided chromosomal sex in its definition. Perhaps because of Swyer syndrome as mnetioned in the article.

  • beardyw 9 hours ago

    I thinks "undifferentiated" would make the point just as well.

carlmr 10 hours ago

>to the sex that produces the large reproductive cell

What is the large reproductive cell? The egg?

bediger4000 4 hours ago

There's 5α-Reductase 2 deficiency. How does that get accounted for?

lazide 10 hours ago

I guess that is one way to solve the under representation in tech?

reify 7 hours ago

a more balanced view based on fact

https://consensus.app/questions/every-embryo-start-female/

Does every embryo start out as female?

Searched over 200M research papers

Analyzed relevant papers

Conclusion

In summary, while genetic sex is determined at fertilization, early embryonic development is inherently female unless influenced by male-specific factors. Both male and female contributions are crucial for normal embryo development, and certain kinetic parameters can help predict embryo sex. Additionally, a female bias in HESC lines highlights the resilience of female embryos under specific culture conditions. These findings collectively enhance our understanding of embryonic sex differentiation and development.

  • JumpCrisscross 7 hours ago

    The difference in quality between this and the top comment reifies the downsides of AI for analysis.

    Also, this is pure bullshit: “These findings collectively enhance our understanding of embryonic sex differentiation and development.” I don’t even think a university press office would write something that meaningless.

dinkumthinkum 3 hours ago

I think the author of this article just has trouble with reading comprehension or they interpreted this in a childish way to make a click-bait article. It's really not that complicated.