I reckon I'll buy some landscaping machinery and a truck before I ever sign up for that distopian nightmare. At least sound ordinance would prevent 24/7 operation.
on the recreational level, maybe, but from a therapeutic perspective for people who actually benefit from its prescribed use its absolutely game-changing to live a life without (or with mitigated) executive dysfunction.
A lot of people with ADHD that have success with medication can tell you that it's not just about work.
It also helps with non-work stuff that's just not fun to do, such as chores or filing your taxes. It even helps you stick with hobbies you actually enjoy but your brain gets bored of.
I know you're joking but I saw a company that had similar policies like fasting and stuff like that to improve productivity. They seemed to take it pretty seriously...
My partner has had idiopathic hypersomnia (sleeps 12 hours most days, as much as 18 hours some days) for a few years now, and so far nothing we’ve tried has worked without awful side effects (e.g. constant heart palpitations and panic attacks.)
I had been looking into orexin agonists (along with other things like H3 autoreceptor antagonists) back when they were just a concept. It’s good to see them finally reaching commercialization. Although they’re not approved by our own (Canadian) regulatory body quite yet.
Now that they’re approved in the US, though, I’m looking very much forward to seeing how these drugs perform in off-label-ish treatment of the various other sleep disorders that I’m sure clinicians will now begin throwing them at.
Have they tried GHB? I know it's used in narcolepsy patients with great success. If you "microdose" it, it's also one of the best drugs on the planet. Slippery slope, though.
It sounds like is a genuine treatment for those who suffer from narcolepsy, and everything else is merely speculative and has seem pretty bad side-effects.
There is evidence that some forms of ADHD are effectively just the brain falling asleep rapidly and then waking up. This form cam be attenuated with norepinephrine reuptake inhibitor alone. Presents with ADHD like symptoms. But it’s a new thing most likely. Called “Cognitive Disengagement Syndrome”.
> IMO the much more likely explanation is that the brain uses contrastive learning somewhere. [...] Instead of using calculus and outer products to calculate derivatives, you feed real data and false data forward through the network and each neuron tracks and trains on the difference.
That's a technique that was tried in machine learning and worked (although obviously not optimally or we'd all be using it by now) and then we hypothesised that animal brains use it because it would explain sleep.
Despite the stigma surrounding semaglutide, its impact across various health conditions has been remarkable. Bringing that same level of innovation to cognitive disorders could be truly transformative for society
If this means I don't have to take Methylphenidate to function 100% all the time and as a result feel tremendously anxious 100% all the time. SIGN ME UP.
Adding guanfacine (Intuniv) to my methylphenidate took the weird anxious-angry edge off. Would be nice to not have to take one med to fix the side effects of the other, though.
Everyone involved in a stock market agrees it's quite useful to have a separation between days, although you could have a 23.5/7 stock market with only half hour day-ends. That's when things like index rebalancing, addition, removal, stock splits occur. You say whoever holds stock X at end of a certain day holds stock Y+Z at the start of the next day (due to a company splitting up) and there's no need to argue about which millisecond a trade occurred. (It's your own damn fault if you were trying to buy the stock in the milliseconds before closing, but some exchanges run a special closing auction with a different algorithm to prevent races). It's also the time you can deploy software, which you can't do during the day. Maybe half an hour is too short for all this stuff. Or maybe it should be a 12 hour window once a week instead.
The second I read the print in Nature a bit ago I knew some version would show up here. I swear I’ve met deployed Marines less obsessed with staying awake through chemistry than some people here.
To get a job at our company take three pills of brainOzempic every day to maximize productivity.
We have our NeuroLinkBrain Implant plugin to AI agent , so that you can vibe code 24/7 . To maximize shareholder value.
I reckon I'll buy some landscaping machinery and a truck before I ever sign up for that distopian nightmare. At least sound ordinance would prevent 24/7 operation.
No more sound ordinance, just install Neuralink and receive free auto-mute during sleeping hours.
Is this supposed to be scary or amazing?
Your comment is probably the most disturbing thing I’ve ever read on this website
I dunno, there's been a whole lot of fascist bootlicking going on lately under the guise of good faith discussion. That's pretty disturbing to me.
Isn't this already happening with ADHD drugs?
on the recreational level, maybe, but from a therapeutic perspective for people who actually benefit from its prescribed use its absolutely game-changing to live a life without (or with mitigated) executive dysfunction.
A lot of people with ADHD that have success with medication can tell you that it's not just about work.
It also helps with non-work stuff that's just not fun to do, such as chores or filing your taxes. It even helps you stick with hobbies you actually enjoy but your brain gets bored of.
Don't tell me psychiatrist but I take my addon Ritalin at night so I can play games or read a book. I just can't do it without it
I know you're joking but I saw a company that had similar policies like fasting and stuff like that to improve productivity. They seemed to take it pretty seriously...
My partner has had idiopathic hypersomnia (sleeps 12 hours most days, as much as 18 hours some days) for a few years now, and so far nothing we’ve tried has worked without awful side effects (e.g. constant heart palpitations and panic attacks.)
I had been looking into orexin agonists (along with other things like H3 autoreceptor antagonists) back when they were just a concept. It’s good to see them finally reaching commercialization. Although they’re not approved by our own (Canadian) regulatory body quite yet.
Now that they’re approved in the US, though, I’m looking very much forward to seeing how these drugs perform in off-label-ish treatment of the various other sleep disorders that I’m sure clinicians will now begin throwing them at.
Have they tried GHB? I know it's used in narcolepsy patients with great success. If you "microdose" it, it's also one of the best drugs on the planet. Slippery slope, though.
Well, they're filming the next season of black mirror right now, it's probably not too late to throw this one in there.
It sounds like is a genuine treatment for those who suffer from narcolepsy, and everything else is merely speculative and has seem pretty bad side-effects.
There is evidence that some forms of ADHD are effectively just the brain falling asleep rapidly and then waking up. This form cam be attenuated with norepinephrine reuptake inhibitor alone. Presents with ADHD like symptoms. But it’s a new thing most likely. Called “Cognitive Disengagement Syndrome”.
https://archive.md/LWDUq
I like sleep - it's not a problem to be solved.
185 comments 2 weeks ago: https://news.ycombinator.com/item?id=49263658
Interesting comment: https://news.ycombinator.com/item?id=49264602
> IMO the much more likely explanation is that the brain uses contrastive learning somewhere. [...] Instead of using calculus and outer products to calculate derivatives, you feed real data and false data forward through the network and each neuron tracks and trains on the difference.
I'm curious if there is an explanation for it not being more common to sleep like dolphins do, small parts of the brain at a time.
Separately, do I understand the idea correctly:
- when learning on the real examples, just propagate forward
- when learning on the fake examples, first generate them by propagating white noise backward
That's a technique that was tried in machine learning and worked (although obviously not optimally or we'd all be using it by now) and then we hypothesised that animal brains use it because it would explain sleep.
Despite the stigma surrounding semaglutide, its impact across various health conditions has been remarkable. Bringing that same level of innovation to cognitive disorders could be truly transformative for society
If this means I don't have to take Methylphenidate to function 100% all the time and as a result feel tremendously anxious 100% all the time. SIGN ME UP.
You sure about that math?
I'm honestly not sure about anything man
Adding guanfacine (Intuniv) to my methylphenidate took the weird anxious-angry edge off. Would be nice to not have to take one med to fix the side effects of the other, though.
Interesting, will check it out. Cheers!
My son takes the methylphenidate / guanfacine combo as well and it’s been a game changer.
Any other benefits?
Sleep less and sit more. What a species we’ve become.
"Others are exploring their use for treating sleep apnoea, which is a far more common disorder." CPAP biomedical equipment manufacturer watch out!
Aw hell no
24/7 stock market, least sleep needed, most AI piled, I’m very excited!
Cryptocurrency markets are open 24/7 btw.
Everyone involved in a stock market agrees it's quite useful to have a separation between days, although you could have a 23.5/7 stock market with only half hour day-ends. That's when things like index rebalancing, addition, removal, stock splits occur. You say whoever holds stock X at end of a certain day holds stock Y+Z at the start of the next day (due to a company splitting up) and there's no need to argue about which millisecond a trade occurred. (It's your own damn fault if you were trying to buy the stock in the milliseconds before closing, but some exchanges run a special closing auction with a different algorithm to prevent races). It's also the time you can deploy software, which you can't do during the day. Maybe half an hour is too short for all this stuff. Or maybe it should be a 12 hour window once a week instead.
A better modafinil? Sign me up.
The second I read the print in Nature a bit ago I knew some version would show up here. I swear I’ve met deployed Marines less obsessed with staying awake through chemistry than some people here.
Hooray fatal insomnia
wow. now i'm really excited for the future